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Trends Microbiol. 1999 Sep;7(9):356-61.

The interaction between RTX toxins and target cells.

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Leon Levy Research Center for Oral Biology, School of medicine, University of Pennsylvania, Philadelphia, PA 19104-6002, USA.


RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They fall into two categories: the hemolysins, which affect a variety of cell types, and the leukotoxins, which are cell-type- and species-specific. These toxins offer interesting models for targeting, insertion and translocation of aqueous proteins into lipid membranes.

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