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Curr Biol. 1999 Jul 29-Aug 12;9(15):R568-71.

Receptor signaling: when dimerization is not enough.

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1
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

Activation of receptors that signal via tyrosine kinase domains has been thought to involve receptor dimerization and transphosphorylation of juxtaposed catalytic domains. Recent results suggest things might be more complex - specific intersubunit conformational changes within a dimer can also be important.

PMID:
10469554
DOI:
10.1016/s0960-9822(99)80357-1
[Indexed for MEDLINE]
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