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Am J Cardiol. 1999 Aug 15;84(4):462-6, A9.

Histopathologic comparison of human coronary in-stent and post-balloon angioplasty restenotic tissue.

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The Gill Heart Institute, University of Kentucky, Lexington, USA.


Histomorphometric studies for smooth muscle cells, macrophages, tissue factor, collagen, and cell proliferation were performed on 20 atherectomy specimens from patients with in-stent restenosis and 20 specimens from patients with post-balloon PTCA restenosis. Smooth muscle cell content was larger and proliferation index was higher in in-stent restenotic tissue; macrophage, tissue factor, and collagen content were larger in post-balloon percutaneous transluminal coronary angioplasty restenotic tissue, suggesting a more cellular and proliferative response with less thrombogenic potential in human tissue from in-stent restenosis than tissue from post-balloon percutaneous transluminal coronary angioplasty restenosis.

[Indexed for MEDLINE]

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