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J Pediatr Gastroenterol Nutr. 1999 Sep;29(3):282-5.

Gluten-free diet decreases urinary peptide levels in children with celiac disease.

Author information

1
Department of Pediatrics, Buskerud Central Hospital, Drammen, Norway.

Abstract

BACKGROUND:

Increased urine secretion of peptides has been found in celiac disease, probably resulting from increased intestinal uptake of peptides caused by damage to the small gut mucosa.

METHODS:

High-performance liquid chromatography of low-molecular-weight peptides in the urine was performed over 6 months, before and after a gluten-free diet was instituted in children who clinically improved while consuming the diet.

RESULTS:

A significant decrease of peptide levels was observed in children consuming the gluten-free diet. Certain peptide peaks thought to be gluten related decreased the most after the patients began the diet.

CONCLUSIONS:

Because the peptides decrease in patients consuming a gluten-free diet, it is reasonable to conclude that such peptides have a mostly dietary origin.

PMID:
10467992
[Indexed for MEDLINE]

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