Format

Send to

Choose Destination
See comment in PubMed Commons below
Immunol Res. 1999;20(1):67-78.

Murine mercury-induced autoimmunity: a model of chemically related autoimmunity in humans.

Author information

1
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

Abstract

Human exposure to certain compounds or therapeutic drugs can result in the development of an autoimmune syndrome. Mercury (Hg) induced autoimmunity is one of the few animal models in which administration of a chemical induces a specific loss of tolerance to self-antigens. After receiving subtoxic doses of Hg or other heavy metals, susceptible mouse strains rapidly develop highly specific antibodies to nucleolar antigens. In addition, these animals display a general activation of the immune system, especially pronounced for the Th2 subset and a transient glomerulonephritis with immunoglobulin deposits. Like many human autoimmune diseases, this syndrome is associated with the expression of susceptible major histocompatibility complex (MHC) class II genes. In this article, we review the essential features of this model, and we discuss the putative mechanisms by which Hg creates such a severe immune dysfunction.

PMID:
10467984
DOI:
10.1007/BF02786508
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center