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Am Heart J. 1999 Sep;138(3 Pt 1):456-9.

Can beta-blocker therapy be withdrawn from patients with dilated cardiomyopathy?

Author information

1
Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Abstract

BACKGROUND:

It has yet to be determined whether withdrawing beta-blocker therapy from patients with dilated cardiomyopathy (DCM) is safe.

METHODS:

The influence of tapering and then stopping metoprolol was clarified in 13 patients with DCM who had been receiving this agent for >/=30 months.

RESULTS:

Seven of the 13 patients deteriorated, including 4 who died suddenly or of congestive heart failure during the 4-month period after metoprolol cessation.

CONCLUSION:

In patients with DCM in whom beta-blocker therapy is effective, withdrawal of these agents may lead to death. We conclude that beta-blockers should not be stopped in this patient group.

PMID:
10467195
[Indexed for MEDLINE]

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