Send to

Choose Destination
See comment in PubMed Commons below
Neurobiol Aging. 1999 Jan-Feb;20(1):9-18.

Age-related psychomotor and spatial learning deficits in 129/SvJ mice.

Author information

Laboratory of Cellular and Molecular Biology, Molecular Physiology and Genetics Section, National Institute on Aging, Intramural Research Program, Gerontology, Research Center, Baltimore, MD 21224, USA.


The 129 mouse strain has been widely used to construct mutations that model behavioral aging in humans. The current study found significant age-related declines in both psychomotor and swim maze performance of 5-, 17-, and 27-month-old 129/SvJ mice. However, the age differences in swim maze acquisition were inconsistent with poor performance in the probe trial which assesses spatial memory. This inconsistency may result from the high degree of genetic polymorphisms and age-related visual pathology which afflicts this mouse strain. Therefore, we concluded that 129/SvJ mice present a problematic model of mammalian cognitive aging and involve a risk for behavioral contamination in studies involving mutant mice derived from this strain.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center