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Psychiatry Res. 1999 Jun 30;90(3):193-9.

Visual assessment of medical temporal lobe atrophy in demented and healthy control subjects: correlation with volumetry.

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1
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute B56, Huddinge University Hospital, Sweden. lars-olof.wahlund@cnsf.ki.se

Abstract

The present study evaluated the validity of visual rating of medial temporal lobe atrophy on coronal magnetic resonance imaging scans in a population of demented and non-demented individuals. Medial temporal lobe atrophy in 194 subjects was visually rated from hard copies, using a 0-4 rating scale, and a comparison was made with the absolute volumes (ccm) of the medial temporal lobe as estimated with volumetry, using a stereological method. We found a highly significant correlation between the estimated and stereologically measured volumes. There was a 10-fold difference in time spent on rating medial temporal lobe atrophy (1-2 min) vs. time spent calculating the medial temporal lobe volume (10-12 min) on a single subject. The diagnostic accuracy of both methods showed that visual rating was more efficient than volumetry in differentiating Alzheimer's disease from control subjects, We conclude that visual rating is a reliable and fast method to estimate medial temporal lobe atrophy in demented subjects in a clinical setting.

PMID:
10466738
DOI:
10.1016/s0925-4927(99)00016-5
[Indexed for MEDLINE]

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