Determination of extent and activity with radionuclide imaging in Erdheim-Chester disease

Clin Nucl Med. 1999 Apr;24(4):252-5. doi: 10.1097/00003072-199904000-00007.

Abstract

Erdheim-Chester disease usually involves the diaphyseal and metaphyseal regions of tubular bones and various visceral organs. A 56-year-old woman presented with the histologically confirmed diagnosis of Erdheim-Chester disease. A Tc-99m MDP bone scan revealed the entire extent of the skeletal disease and showed unusual involvement of the epiphyses and axial skeleton. In addition to MRI, a Ga-67 citrate scan including SPECT showed extensive soft-tissue infiltration of different organs. Both Tc-99m MDP and Ga-67 scintigraphy are useful tools in determining the distribution of this rare disease.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Bone Diseases / diagnostic imaging*
  • Bone Diseases / pathology
  • Brain Diseases / diagnostic imaging
  • Diaphyses / diagnostic imaging
  • Epiphyses / diagnostic imaging
  • Female
  • Foam Cells / pathology
  • Gallium Radioisotopes
  • Humans
  • Joint Diseases / diagnostic imaging
  • Middle Aged
  • Orbital Diseases / diagnostic imaging
  • Parotid Diseases / diagnostic imaging
  • Radiopharmaceuticals
  • Technetium Tc 99m Medronate
  • Tomography, Emission-Computed, Single-Photon
  • Xanthomatosis / diagnostic imaging*
  • Xanthomatosis / pathology

Substances

  • Gallium Radioisotopes
  • Radiopharmaceuticals
  • Technetium Tc 99m Medronate