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Neuropharmacology. 1999 Jun;38(6):913-6.

Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: role of antioxidation.

Author information

1
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.

Abstract

Recombinant human GDNF was infused into the rat striatum either acutely or subchronically. Its effects and its interactions with MPP+ on antioxidant enzyme activities were examined. Results indicated that acute GDNF infusion significantly increased glutathione peroxidase, superoxide dismutase and catalase activities. Subchronic GDNF treatment decreased the DA level and enhanced DA turnover. Pre-treatment with GDNF markedly protected DA neurons against MPP+-induced toxicity. These results suggest that GDNF protects DA neurons through its activation of the antioxidant enzyme systems.

PMID:
10465695
DOI:
10.1016/s0028-3908(99)00030-1
[Indexed for MEDLINE]

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