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Bioorg Med Chem Lett. 1999 Aug 2;9(15):2273-8.

Synthesis and biological evaluation of a new class of vaccine adjuvants: aminoalkyl glucosaminide 4-phosphates (AGPs).

Author information

1
Pharmaceutical Discovery Division, Ribi ImmunoChem Research, Inc., Hamilton, MT 59840, USA.

Abstract

A novel series of acylated omega-aminoalkyl 2-amino-2-deoxy-4-phosphono-beta-D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesized and screened for immunostimulant activity. Several of these compounds enhance the production of tetanus toxoid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells.

PMID:
10465560
DOI:
10.1016/s0960-894x(99)00374-1
[Indexed for MEDLINE]

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