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Bioorg Med Chem Lett. 1999 Aug 2;9(15):2233-6.

3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands.

Author information

1
Unité de Chimie Pharmaceutique et de Radiopharmacie, Université Catholiqué de Louvain, Bruxelles, Belgium.

Abstract

Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.

PMID:
10465552
DOI:
10.1016/s0960-894x(99)00353-4
[Indexed for MEDLINE]

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