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Trends Genet. 1999 Sep;15(9):358-63.

RNA-triggered gene silencing.

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Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA.


Double-stranded RNA (dsRNA) has recently been shown to trigger sequence-specific gene silencing in a wide variety of organisms, including nematodes, plants, trypanosomes, fruit flies and planaria; meanwhile an as yet uncharacterized RNA trigger has been shown to induce DNA methylation in several different plant systems. In addition to providing a surprisingly effective set of tools to interfere selectively with gene function, these observations are spurring new inquiries to understand RNA-triggered genetic-control mechanisms and their biological roles.

[Indexed for MEDLINE]

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