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Trends Endocrinol Metab. 1999 Sep;10(7):262-267.

The PTB Domain: The Name Doesn't Say It All.

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Howard Hughes Medical Institute, Departments of Internal Medicine and Biological Chemistry, University of Michigan Medical School, 4570 MSRB II, Box 0650, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0650, USA.


The phosphotyrosine-binding domain is a recently described protein-protein interaction domain which, despite its name, is involved in both phosphotyrosine-dependent and -independent interactions. Proteins with this domain are involved in diverse cellular functions, ranging from receptor signaling to protein targeting.

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