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Drug Discov Today. 1999 Sep;4(9):431-439.

Cell-based assays and instrumentation for screening ion-channel targets.

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Aurora Biosciences Corp, 11010 Torreyana Road, San Diego, CA 92121, USA.


Ion channels are an important class of drug targets. They comprise the molecular basis for essential physiological functions including fluid secretion, electrolyte balance, bioenergetics and membrane excitability. High-throughput screening for ion-channel function requires sensitive, simple assays and instrumentation that will report ion channel activity in living cells. This article will review relevant assay technologies for ion channels and describe voltage-sensitive probes and instruments based on fluorescence resonance energy transfer (FRET) that enable ion-channel drug discovery.


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