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Psychiatry Clin Neurosci. 1999 Apr;53(2):203-5.

Analysis of rapid eye movement periodicity in narcoleptics based on maximum entropy method.

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College of Medical Technology, Hokkaido University, Sapporo, Japan.


We examined REM sleep periodicity in typical narcoleptics and patients who had shown signs of a narcoleptic tetrad without HLA-DRB1*1501/DQB1*0602 or DR2 antigens, using spectral analysis based on the maximum entropy method. The REM sleep period of typical narcoleptics showed two peaks, one at 70-90 min and one at 110-130 min at night, and a single peak at around 70-90 min during the daytime. The nocturnal REM sleep period of typical narcoleptics may be composed of several different periods, one of which corresponds to that of their daytime REM sleep.

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