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Curr Opin Microbiol. 1999 Aug;2(4):438-43.

Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses.

Author information

1
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. mmcdowell@niaid.nih.gov

Abstract

Leishmania parasites are able to delay the onset of cell-mediated immunity by selectively impairing the ability of infected macrophages to produce interleukin (IL)-12. Leishmania infection arrests the JAK/STAT-mediated signal transduction involved in activation of the IL-12 p40 promoter; the phosphorylation defects may be initiated by ligation of the phagocyte receptors used by these organisms to gain entry into the host cell.

PMID:
10458990
DOI:
10.1016/S1369-5274(99)80077-0
[Indexed for MEDLINE]

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