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Curr Opin Microbiol. 1999 Aug;2(4):382-7.

Immune deficiency, immune silencing, and clonal exhaustion of T cell responses during viral infections.

Author information

1
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. raymond.welsh@ummed.edu

Abstract

Analyses of the complex regulatory networks leading to T cell survival, death, and immune deficiency have been aided in the past year by the dramatic development of new technologies to identify T cells and assess T cell function. These new techniques have shown that functional inactivation and apoptotic elimination of both virus-specific and non-virus-specific T cell populations mold T cell responses to viral infections.

PMID:
10458980
DOI:
10.1016/s1369-5274(99)80067-8
[Indexed for MEDLINE]

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