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Am J Ophthalmol. 1999 Aug;128(2):242-4.

Microbiologic spectrum and susceptibility of isolates: part II. Posttraumatic endophthalmitis. Endophthalmitis Research Group.

Author information

1
Department of Ophthalmology, Harvard Medical School, Cambridge, Massachusetts, USA.

Abstract

PURPOSE:

To present the microbial spectrum and susceptibilities of isolates in posttraumatic endophthalmitis.

METHOD:

Isolates from 182 eyes of 182 patients who underwent vitrectomy for posttraumatic endophthalmitis were examined.

RESULTS:

One hundred thirteen (62.1%) of 182 vitreous samples were culture-positive, and 23 (20.4%) of 113 culture-positive cases were polymicrobial, including three (2.7%) trimicrobial cases, yielding a total of 139 isolates. Isolates included 63 (45.3%) gram-positive cocci, 24 (17.3%) gram-positive bacilli, 25 (18.0%) gram-negative organisms, seven (5.0%) Actinomycetes-related organisms, and 20 (14.4%) fungi. Susceptibilities to amikacin, ceftazidime, chloramphenicol, cefazolin, ciprofloxacin, gentamicin, and vancomycin are reported.

CONCLUSIONS:

This study represents a large series on microbial spectrum and susceptibilities in posttraumatic endophthalmitis. We report a high prevalence of gram-positive bacilli species and polymicrobial infections containing gram-negative species, underscoring the importance of broad-spectrum, combination antibiotics in the empiric treatment of posttraumatic endophthalmitis.

PMID:
10458188
[Indexed for MEDLINE]

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