The left panel demonstrates the maximal GABA
A receptor-mediated IPSP that could be elicited by a single stimulus in s. moleculare under control conditions. When the same stimulus is delivered after increasing [K
+]
o from 2.5 to 8.5 mM, the amplitude of the hyperpolarizing component is decreased and a late depolarizing response is seen (
n = 4). The right panel shows the output of the computer model. The waveform of the control response was matched to the control IPSP by optimizing the dendritic volume, the Cl
− transport parameters, and the time course of the GABA conductance. The same parameters were then used to produce the GABA response in 8.5 mM

; the RMP was set to the experimentally observed values, the
vmax of the transport rate was decreased (;) from 5 to 1 mmol l
−1 s
−1, and the amplitude of the GABA conductance was increased by 20 % to reflect increased excitability of the interneuron in elevated [K
+]
o ().