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Curr Opin Nephrol Hypertens. 1999 May;8(3):293-8.

Glomerular inflammation: use of genetically deficient mice to elucidate the roles of leukocyte adhesion molecules and Fc-gamma receptors in vivo.

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Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.


Single gene knock-outs in mice have been used to define the biological role of leukocyte adhesion receptors, Fc-gamma receptors and complement in animal models of immune complex glomerulonephritis. These studies have shown important differences in the role of P-selectin in glomerular inflammation and inflammation at other sites, and have given a new appreciation of the dominant role played by Fc-gamma receptors in immune complex-induced glomerular injury.

[Indexed for MEDLINE]

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