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Am J Obstet Gynecol. 1999 Aug;181(2):348-52.

Mammographic breast density during hormone replacement therapy: differences according to treatment.

Author information

1
Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.

Abstract

OBJECTIVE:

Our purpose was to investigate the effects of various hormone replacement regimens on mammographic breast density.

STUDY DESIGN:

Mammographic density was recorded in women participating in a population-based screening program. All women were nonusers of hormone replacement therapy at first mammogram and thereafter reported continuous use of the same treatment: estrogen alone (n = 50) or estrogen in cyclic (n = 75) or continuous (n = 50) combination with progestogen. Mammographic density was quantified according to the Wolfe classification.

RESULTS:

An increase in mammographic density was much more common among women receiving continuous combination hormone replacement therapy (52%) than among those receiving cyclic (13%) and estrogen-only (18%) treatment. The increase in density was apparent already at first visit after the start of hormone replacement therapy. There was little change in mammographic status during long-term follow-up.

CONCLUSION:

Regimens of hormone replacement therapy were shown to have different effects on the normal breast. There is an urgent need to clarify the biologic nature and significance of a change in mammographic density during treatment and, in particular, its relation to symptoms and breast cancer risk.

PMID:
10454681
DOI:
10.1016/s0002-9378(99)70560-0
[Indexed for MEDLINE]

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