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Chest. 1999 Aug;116(2):569-72.

Interferon-alpha therapy associated with the development of sarcoidosis.

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1
Department of Medicine, University of Rochester Medical Center, NY 14642-8692, USA. AnthonyvPietropaoli@URMC.rochester.edu

Abstract

Interferons (IFNs) have been implicated in the pathogenesis of sarcoidosis. In particular, IFN-gamma has been linked to pulmonary macrophage activation, a characteristic feature of sarcoidosis. IFN-alpha is now being administered therapeutically in a variety of conditions. To date, IFN-alpha has not been implicated in the pathogenesis of sarcoidosis. We report the case of a 50-year-old woman who developed sarcoidosis while being treated with IFN-alpha for chronic myelogenous leukemia. Her disease activity correlated with the dosage of IFN-alpha. We speculate that the immunomodulatory effects of IFN-alpha triggered clinical manifestations of sarcoidosis in this patient.

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PMID:
10453892
DOI:
10.1378/chest.116.2.569
[Indexed for MEDLINE]

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