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Surg Oncol Clin N Am. 1999 Oct;8(4):641-56, vi.

The potential of molecular screening.

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  • 1Department of Surgery, The Medical College of Wisconsin, Milwaukee, Wisconsin 53326, USA.

Abstract

Clonal genetic alterations such as tumor suppressor, gene mutations, or microsatellite instability are a hallmark of human cancer. These genetic alterations can be detected in clinical samples using DNA amplification techniques and used for early detection of cancer. This article reviews molecular-based approaches for screening of malignancies commonly encountered by the practicing general surgeon.

PMID:
10452932
[PubMed - indexed for MEDLINE]
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