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Bioorg Med Chem Lett. 1999 Jul 19;9(14):2105-8.

1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase.

Author information

1
Welsh School of Pharmacy, Cardiff University, UK.

Abstract

The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles is described. The compounds were tested for human placental aromatase inhibition in vitro, using [1beta-3H]-androstenedione as the substrate for the aromatase enzyme, the percentage inhibition and IC50 data is included.

PMID:
10450990
DOI:
10.1016/s0960-894x(99)00328-5
[Indexed for MEDLINE]

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