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Bioorg Med Chem Lett. 1999 Jul 19;9(14):1985-90.

The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase.

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1
AgrEvo UK Limited, Essex, England. stephen.lindell@agrevo.com

Abstract

Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5'-monophosphate deaminase (AMPDA) following phosphorylation of the 5'-hydroxyl group in vivo. The search for more stable and accessible structures led to the synthesis of carbocyclic nebularine (8) and deaminoformycin (10). The latter compound is a good herbicide and its corresponding 5'-monophosphate 14 is a strong inhibitor of plant AMPDA (IC50 100 nM).

PMID:
10450967
[Indexed for MEDLINE]
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