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World J Surg. 1999 Sep;23(9):907-12.

Improving results of pancreaticoduodenectomy for pancreatic cancer.

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Department of Surgery, Johns Hopkins Hospital, The Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Blalock 606, Baltimore, Maryland 21287-4606, USA.


This report from The Johns Hopkins Hospital reviews the results of pancreaticoduodenal resection during the decade of the 1990s, focusing on two recent publications. The first to be discussed involves a cohort of 650 consecutive patients undergoing pancreaticoduodenectomy (PD), with 443 patients having periampullary adenocarcinomas, 282 of whom had a pathologic diagnosis of pancreatic adenocarcinoma. The second report to be discussed involves the use of adjuvant chemoradiation therapy in a cohort of 174 patients who had successfully undergone PD for pancreatic adenocarcinoma. In both of these cohorts the operative mortality was less than 2%, and the median survival for resected pancreatic adenocarcinoma approximated 20 months.

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