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Curr Opin Genet Dev. 1999 Aug;9(4):422-6.

Diverse initiation in a conserved left-right pathway?

Author information

1
Huntsman Cancer Institute, University of Utah, 2000 E. North Campus Drive, Room 452, Salt Lake City, Utah 84112-5550, USA. joseph.yost@hci.utah.edu

Abstract

Preceding stereotypical left-right asymmetric morphogenesis, asymmetric gene expression patterns of nodal and pitx2 are very similar in major groups of vertebrates. I propose that these conserved expression patterns are indicative of 'left-right' phylotypic stages' of development. It is not known whether these patterns are initiated by conserved or divergent developmental mechanisms.

PMID:
10449359
DOI:
10.1016/s0959-437x(99)80064-1
[Indexed for MEDLINE]

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