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Curr Opin Genet Dev. 1999 Aug;9(4):466-72.

Roles of the JNK signaling pathway in Drosophila morphogenesis.

Author information

1
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachussetts 02115, USA. snoselli@rascal.med.harvard.edu

Abstract

Epithelial cell differentiation and morphogenesis are crucial in many aspects of metazoan development. Recent genetic studies in Drosophila have revealed that the conserved Jun amino-terminal kinase (JNK) signaling pathway regulates epithelial morphogenesis during the process of embryonic dorsal closure and participates in the control of planar polarity in several tissues. Importantly, these studies have linked the JNK pathway to the decapentaplegic and Frizzled pathways in these processes, suggesting a high degree of integrative signaling during epithelial morphogenesis.

PMID:
10449347
DOI:
10.1016/S0959-437X(99)80071-9
[Indexed for MEDLINE]

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