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Curr Opin Biotechnol. 1999 Aug;10(4):341-8.

Design and application of multimodular peptide synthetases.

Author information

1
Fachbereich Chemie/Biochemie, Philipps-Universit├Ąt Marburg, Hans-Meerwein-Strasse, 35032, Marburg, Germany. Mootz@ps1515.chemie.uni-marburg.de

Abstract

Nonribosomal peptide synthetases produce bioactive peptides of great structural diversity. Their modular organization makes them amenable to the construction of hybrid enzymes that synthesize novel products. New strategies for combinatorial approaches are being developed from the recent advances in nonribosomal peptide synthesis on the genetic, biochemical and structural level.

PMID:
10449311
DOI:
10.1016/S0958-1669(99)80062-7
[Indexed for MEDLINE]

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