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Arch Neurol. 1999 Aug;56(8):951-7.

Diffusion-weighted magnetic resonance imaging in probable Creutzfeldt-Jakob disease: a clinical-anatomic correlation.

Author information

1
Department of Neurology, College of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul, Korea.

Abstract

BACKGROUND:

Creutzfeldt-Jakob disease (CJD) is a rare transmissible disease that typically causes a rapidly progressive dementia and leads to death in less than 1 year. Although a few anecdotal reports suggest that diffusion-weighted magnetic resonance imaging may help substantiate premortem diagnosis of CJD, detailed correlation between radiographic data and clinical, electrophysiologic, and metabolic parameters is not available.

METHODS:

Signal abnormalities on diffusion-weighted images in 3 consecutive patients with probable CJD were correlated with psychometric features, electroencephalographic findings, and functional images with either positron emission tomography or single photon emission computed tomography.

RESULTS:

Focality of abnormalities on diffusion-weighted image, not apparent on routine magnetic resonance images, correlated closely with clinical manifestations of CJD. The topographic distribution of signal abnormality on diffusion-weighted image corresponded with abnormal metabolism or perfusion on positron emission and single photon emission computed tomographic scans. In 2 cases, the laterality of diffusion abnormalities correlated with periodic sharp wave activity on electroencephalograms.

CONCLUSION:

These findings extend previous observations that suggested a diagnostic and localizing utility of diffusion-weighted imaging in CJD.

PMID:
10448800
DOI:
10.1001/archneur.56.8.951
[Indexed for MEDLINE]

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