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Clin Lab Haematol. 1999 Jun;21(3):207-10.

Multiple chromosomal abnormalities in fulminant anaplastic myeloma.

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  • 1Hematology Institute, Barzilai Medical Center, Ashkelon, Israel.

Abstract

We describe a 58-year-old woman with anaplastic multiple myeloma and multiple chromosomal abnormalities. Her karyotype showed extreme hyperploidy with 77 chromosomes. Some of the aberrations were typical of multiple myeloma (+3, +5, +15, +19, +21, t(11;14)(q13;q32)), others were characteristic of the aggressive anaplastic myeloma (+8), t(11;14)(q13;q32), while three chromosomal abnormalities (t(11;20)(p11;q13); t(4;7)(q31;q11); and t(14;20)(q24;q13)) have not been, to the best of our knowledge, described previously in the literature. The fulminant course of the disease confirms the poor prognosis of multiple karyotypic abnormalities in myeloma.

PMID:
10448603
[PubMed - indexed for MEDLINE]
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