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Nat Neurosci. 1999 Jun;2(6):508-14.

Dendritic lh normalizes temporal summation in hippocampal CA1 neurons.

Author information

1
Neuroscience Center, Louisiana State University Medical Center, 2020 Gravier St., New Orleans, Louisiana 70112, USA. jmagee@lsumc.edu

Abstract

Most mammalian central neurons receive synaptic input over complicated dendritic arbors. Therefore, timing of synaptic information should vary with synapse location. However, I report that temporal summation at CA1 pyramidal somata does not depend on the location of synaptic input. This spatial normalization of temporal integration requires a dendritic hyperpolarization-activated current (lh). Shaping of synaptic activity by deactivating a nonuniform lh could counterbalance filtering by dendrites and effectively remove location-dependent variability in temporal integration, thus enhancing synchronization of neuronal populations and functional capabilities of the hippocampal CA1 region.

PMID:
10448214
DOI:
10.1038/9158
[Indexed for MEDLINE]

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