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Curr Opin Immunol. 1999 Aug;11(4):380-6.

Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic.

Author information

1
Saint Louis University School of Medicine, Department of Molecular Microbiology and Immunology, 1402 South Grand Boulevard, St Louis, MO 63104, USA. woldws@slu.edu

Abstract

Adenoviruses encode proteins that block responses to interferons, intrinsic cellular apoptosis, killing by CD8(+) cytotoxic T lymphocytes and killing by the death ligands TNF, Fas ligand and TRAIL. The viral proteins are believed to prolong acute and persistent adenovirus infections. The proteins may prove useful in protecting adenovirus gene therapy vectors and transplanted cells from the immune system.

PMID:
10448144
DOI:
10.1016/S0952-7915(99)80064-8
[Indexed for MEDLINE]

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