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Curr Opin Immunol. 1999 Aug;11(4):406-11.

Receptor mediated subversion of macrophage cytokine production by intracellular pathogens.

Author information

1
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA. dmmosser@astro.temple.edu

Abstract

Appropriately regulated immune responses depend on the controlled production of cytokines from antigen presenting cells. IL-12 synthesis is tightly regulated by several redundant mechanisms. One mechanism of IL-12 regulation involves the cross-linking of surface receptors on macrophages. This pathway may be exploited by intracellular pathogens of macrophages to inhibit IL-12 production and delay or prevent the development of cell mediated immunity.

PMID:
10448139
DOI:
10.1016/s0952-7915(99)80068-5
[Indexed for MEDLINE]

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