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Curr Opin Immunol. 1999 Aug;11(4):420-6.

The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections.

Author information

1
Division of Immunology, University of Cincinnati College of Medicine, PO Box 670563, OH 45267-0563, USA. ffinkelman@mem.po.com

Abstract

Helminth infections induce the production of type 2 cytokines, which contribute both to expulsion of the worms and inflammatory responses that can either protect or damage the host. Although IL-4 has been considered the most critical cytokine for both inflammation and protective immunity, recent observations indicate that IL-13 - a related cytokine - can have equal or even greater importance than IL-4 in inflammatory responses and host protection against infection.

PMID:
10448138
DOI:
10.1016/S0952-7915(99)80070-3
[Indexed for MEDLINE]

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