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Curr Opin Immunol. 1999 Aug;11(4):451-9.

T lymphocyte responses in HIV-1 infection: implications for vaccine development.

Author information

1
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, MGH-East, 5th floor, 149 13th Street, Charlestown, MA 02129, USA. brander@helix.mgh.harvard.edu

Abstract

Substantial progress has been made over the past year in understanding the cellular immune response in HIV pathogenesis. Cytotoxic T lymphocytes play a critical role in establishing the level of viremia and virus-specific Th cell responses appear to affect the in vivo efficacy of cytotoxic T lymphocytes. Together, these new data provide important insights to refocus efforts aimed at immunotherapeutic interventions and vaccine development.

PMID:
10448136
DOI:
10.1016/S0952-7915(99)80076-4
[Indexed for MEDLINE]

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