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Brain Res. 1999 Aug 14;838(1-2):131-5.

Differential expression patterns of inositol trisphosphate receptor types 1 and 3 in the rat suprachiasmatic nucleus.

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Ishida Group of Clock Gene, National Institute of Bioscience and Human Technology, AIST, MITI, 1-1 Higashi, Tsukuba Science City 305-8566, Japan.


Inositol 1,4,5-trisphosphate receptor types 1 (IP(3)-R1) and 3 (IP(3)-R3) were found in the rat suprachiasmatic nucleus (SCN) and the levels of both of IP(3)-R1 and IP(3)-R3 mRNA showed a reciprocal circadian rhythm. IP(3)-R1 immunoreactive cells were localized in neuronal cells in the SCN. In contrast, IP(3)-R3 immunoreactive cells were mainly localized in the astrocytes in the ventrolateral region of the SCN. These results suggest that IP(3)-R1 and IP(3)-R3 may have differential roles in the SCN in the mammalian circadian rhythm.

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