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Mol Genet Metab. 1999 Aug;67(4):261-77.

Human genes involved in chromatin remodeling in transcription initiation, and associated diseases: An overview using the GENATLAS database.

Author information

1
Service de Génétique Médicale, U393 INSERM, Paris, France. roux-rouquie@necker.fr

Abstract

Chromatin structure is inextricably linked to transcription regulation and differentiation. It consists of a multicomponent system, and impairments in such complex arrays may elicit dramatic biological effects and diseases. We present an overview of human genes involved in chromatin remodeling, which consist of the histone acetyltransferase/deacetylase system and the SWI/SNF-like complexes containing DNA-dependent ATPase activity. Special attention is given to the functional and physical interactions in which these components are involved, notably as transcriptional coactivators and/or corepressors of a large variety of genes. Linking seemingly distinct pathways allows integration of individual components into complex genetic and molecular processes and assessment of the underlying molecular bases of diseases. This was performed using GENATLAS (http://www.infobiogen.fr/), a gene database which compiles the information relevant to the mapping efforts from the published literature.

PMID:
10444337
DOI:
10.1006/mgme.1999.2867
[Indexed for MEDLINE]

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