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Am J Hum Genet. 1999 Sep;65(3):885-901.

Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.

Author information

1
Department of Mathematics and Computer Science, Institute for Electronic Systems, Aalborg University, Aalborg, Denmark. claus@cs. auc.dk

Abstract

We apply the method of "blocking Gibbs" sampling to a problem of great importance and complexity-linkage analysis. Blocking Gibbs sampling combines exact local computations with Gibbs sampling, in a way that complements the strengths of both. The method is able to handle problems with very high complexity, such as linkage analysis in large pedigrees with many loops, a task that no other known method is able to handle. New developments of the method are outlined, and it is applied to a highly complex linkage problem in a human pedigree.

PMID:
10441593
PMCID:
PMC1377993
DOI:
10.1086/302524
[Indexed for MEDLINE]
Free PMC Article

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