Format

Send to

Choose Destination
Semin Cell Dev Biol. 1999 Jun;10(3):311-7.

Activin as a morphogen in Xenopus mesoderm induction.

Author information

1
Wellcome/CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge, CB2 1QR, UK.

Abstract

Activin, a member of the Transforming Growth Factor beta (TGF-beta) superfamily, can behave as a morphogen in cells of the early Xenopus embryo by inducing a range of mesodermal genes in a concentration-dependent manner. This review examines the behaviour of activin as it forms a morphogen gradient. It also discusses how a cell can perceive its position in a concentration gradient in order to activate appropriate mesodermal gene responses.

PMID:
10441545
DOI:
10.1006/scdb.1999.0307
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center