Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 1999 Sep;22(9):382-8.

Hippocampal synapses: do they talk to their neighbours?

Author information

1
Division of Neurophysiology, National Institute for Medical Research, London, UK NW7 1AA.

Abstract

Recent experimental findings show that fast synaptic transmission can extend its actions beyond the immediate synaptic cleft. Whether this phenomenon results in significant crosstalk between typical neighbouring synapses remains unclear. This article considers two areas of the hippocampus, the CA1 and dentate gyrus, where important neural processing occurs. The results discussed do not provide a simple answer to the question of whether synapses can 'talk' to their neighbours, but they do reveal crucial physiological constraints that determine the significance of synaptic crosstalk, thus adding considerably to our understanding of chemical synaptic transmission.

PMID:
10441295
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center