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J Periodontol. 1999 Jul;70(7):786-92.

Stress and immunity: implications for viral disease and wound healing.

Author information

1
Department of Medical Microbiology and Immunology, College of Medicine, The Ohio State University, Columbus 43210, USA.

Abstract

It is now well established that psychological stress can downregulate the cellular immune response. Communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine, and immune systems. Stress disrupts the homeostasis of this network, which in turn, alters immune function. In this review, we discuss the role of stress in modulating cellular immune function and the potential health implications of this downregulation.

PMID:
10440641
DOI:
10.1902/jop.1999.70.7.786
[Indexed for MEDLINE]
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