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Scand J Gastroenterol. 1999 Jun;34(6):580-6.

The effect of faecal enema on five microflora-associated characteristics in patients with antibiotic-associated diarrhoea.

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1
Dept. of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.

Abstract

BACKGROUND:

Patients with antibiotic-associated diarrhoea (AAD) show significant disturbances in short-chain fatty acid pattern. In the present study five more microflora-associated characteristics (MACs) were investigated before and after administration of an enema containing faecal microflora from a healthy person on a Western diet.

METHODS:

The functions of the microflora were determined with gas chromatography, electrophoresis, and spectrophotometry.

RESULTS:

The conversion of cholesterol to coprostanol and the concentration of urobilinogen and trypsin were significantly reduced in comparison with healthy persons. The pattern of mucin was altered, but beta-aspartylglycine remained the same as in healthy persons. Enema treatment influenced these functions to different extents.

CONCLUSION:

Most MACs were significantly disturbed in patients with AAD. Administration of a human faecal enema modified these changes and relieved diarrhoea, usually within 4 days.

PMID:
10440607
[Indexed for MEDLINE]
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