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Intern Med. 1999 Aug;38(8):626-31.

Prevalence and characterization of hepatitis C virus in hemodialysis patients.

Author information

1
First Department of Internal Medicine, Nagasaki University School of Medicine.

Abstract

OBJECT:

Chronic hepatitis C virus (HCV) infection is common in hemodialysis (HD) patients. In the present study, the prevalence and properties of HCV in HD patients were analyzed.

METHODS AND RESULTS:

Of 125 HD patients, 34 (27%) were positive for antibody to HCV, and HCV-RNA was detected in 23 (68%) of the 34 patients using reverse transcription polymerase chain reaction. The HCV-RNA sequence analysis did not identify the alterations specific to HD patients with HCV, although one patient had a variant virus containing the deletion of the core gene sequence. When serial changes in the levels of HCV-RNA were evaluated in 15 patients by a branched DNA assay, the values decreased immediately after HD procedure, but returned to the baseline values 2 days after the procedure.

CONCLUSION:

These results indicate that HCV in HD patients is replication-competent, although a transient reduction in the levels of HCV-RNA occurs during HD.

PMID:
10440497
DOI:
10.2169/internalmedicine.38.626
[Indexed for MEDLINE]
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