Format

Send to

Choose Destination
Eur J Pharmacol. 1999 Jul 2;376(1-2):23-6.

Dependence of mesolimbic dopamine transmission on delta9-tetrahydrocannabinol.

Author information

1
Department of Toxicology and Consiglio Nazionale delle Ricerche, Center for Neuropharmacology, University of Cagliari, Italy.

Abstract

Rats were administered daily for 8 days with increasing doses (2-12 mg/kg/day) of delta9-tetrahydrocannabinol (delta9-THC) and than challenged with different doses of SR141716A, an antagonist of cannabinoid receptors. SR141716A dose dependently reduced dialysate dopamine (DA) in the nucleus accumbens shell and precipitated a physical withdrawal syndrome. No such effects were obtained after administration of SR141716A to saline controls.

PMID:
10440085
DOI:
10.1016/s0014-2999(99)00384-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center