This article documents 53 cases of Salmonella paratyphi C infections in humans in the Eastern Transvaal (47 cases) and South West Africa (6 cases). Ninety-two percent of patients (49 cases) had enteric fever, 1 patient was asymptomatic, and 3 had localized urinary infections or were carriers. Most patients were successfully treated with chloramphenicol and only 1 relapsed. The South West African strains were identified as S. paratyphi C var. east africa. The organism is probably spread by water, and 70% of patients who had enteric fever were under the age of 20 years.