Format

Send to

Choose Destination
See comment in PubMed Commons below
Vet Immunol Immunopathol. 1999 May;68(2-4):293-6.

Sheep perforin: identification and expression by gammadelta T cells from pregnant sheep uterine epithelium.

Author information

1
Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia. fox@wehi.edu.au

Abstract

GammadeltaTCR-positive intraepithelial lymphocytes (IEL) in sheep uterus have been shown in previous studies to express CD8 and to contain prominent intracytoplasmic granules, indicating that they may be cytotoxic. Sheep perforin, which has not previously been described, was identified in the present study using RT-PCR based on primers from human and mouse perforin sequences. A 290 base pair (bp), partial sheep perforin sequence was obtained which showed 80.3% and 66.2% nucleotide identity with human and mouse perforin, respectively. GammadeltaTCR+ IEL from sheep pregnant uteri were found to express perforin mRNA providing further evidence that these cells are cytotoxic.

PMID:
10438327
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center