Send to

Choose Destination
Dev Biol. 1999 Aug 15;212(2):414-24.

Cortexillin I is required for development in Polysphondylium.

Author information

Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.


The actin binding proteins cortexillin I and II play a major role in Dictyostelium cytokinesis, in which they are found localized to the membranes of the cleavage furrow. Here we report on cortexillin I mutants isolated by gene trapping in Polysphondylium. The original mutation and reconstructed versions of the original, as well as cortexillin I deletions, are unable to form aggregation streams under starvation conditions. The fruiting bodies that do form when cells are grown on bacterial lawns lack the one- and two-dimensional symmetries so apparent in wild type. These two phenotypes and the proposed structural basis for them suggest that cortexillin I functions in chemotaxis and morphogenesis in addition to its role in cytokinesis.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center