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Dev Biol. 1999 Aug 15;212(2):414-24.

Cortexillin I is required for development in Polysphondylium.

Author information

1
Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA.

Abstract

The actin binding proteins cortexillin I and II play a major role in Dictyostelium cytokinesis, in which they are found localized to the membranes of the cleavage furrow. Here we report on cortexillin I mutants isolated by gene trapping in Polysphondylium. The original mutation and reconstructed versions of the original, as well as cortexillin I deletions, are unable to form aggregation streams under starvation conditions. The fruiting bodies that do form when cells are grown on bacterial lawns lack the one- and two-dimensional symmetries so apparent in wild type. These two phenotypes and the proposed structural basis for them suggest that cortexillin I functions in chemotaxis and morphogenesis in addition to its role in cytokinesis.

PMID:
10433831
DOI:
10.1006/dbio.1999.9353
[Indexed for MEDLINE]
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