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Nucleosides Nucleotides. 1999 Apr-May;18(4-5):891-2.

Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane.

Author information

1
BioChem Therapeutics Inc., Laval, Quebec, Canada.

Abstract

DXG and its prodrug DAPD have been demonstrated to be effective inhibitors of HIV-1 in various cells. The EC50s for DXG were 0.032 microM in CBMCs and 0.05 microM in MT-4 cells, which were generally equipotent as 3TC. 3TC-resistant, but not AZT-resistant, HIV-1 had minimum diminished sensitivity to the compounds. Both DXG and DAPD were non-toxic to cells up to 500 microM.

PMID:
10432704
DOI:
10.1080/15257779908041594
[Indexed for MEDLINE]

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